Human interleukin-10 (IL-10). IL-10 is mainly produced by monocytes and some lymphocytes as a 20.5 kDa, glycosylated homodimeric protein. It is an anti-inflammatory cytokine that inhibits the synthesis of numerous cytokines (including IFN-γ, IL-2, IL-3, TNF-α, TNF-β, and GM-CSF) that suppress Th1 proinflammatory responses involved in promoting phagocytosis.

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It is a cytokine with potent anti-inflammatory properties, repressing the expression of inflammatory cytokines such as TNF-Alpha, IL-6 and IL-1 by activated macrophages IL-10 is a pleiotropic cytokine with important immunoregulatory functions. IL-10 R1: Human IL-10R1 is a 90-110 kDa, type I transmembrane glycoprotein that is expressed on a limited number of cell types. 63 The open reading frame encodes a 578 aa protein that contains a 21 aa ss, a 215 aa extracellular region, a 25 aa transmembrane segment, and a 317 aa cytoplasmic domain. Auburn High School 511 N. 7th St. Auburn, IL 62615 217.438.6817 f: 217.438.6153 Auburn Middle School 601 N. 7th St. Auburn, IL 62615 217.438.6919 f: 217.438.3700 The Tigers placed Miguel Cabrera on the 10-day IL with a left biceps strain and selected the contract of infielder Renato Nunez.

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IL10 interleukin 10. IL10. interleukin 10. Gene ID: 3586, updated on 27-Dec-2020. Gene type: protein coding.

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2014-12-01 · IL-10 binding starts an intracellular signaling pathway involving STAT3 as key translocation nuclear factor which induces the activation of specific gene encoding for anti-inflammatory factors. Figure 2. IL-10 is able to modulate the immune reactivity activating the cellular response via B-Cells and inhibiting the IFN-γ- mediated Th1 response.

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General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. IL10.
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Search results for il-10 at Sigma-Aldrich.
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Interleukin-10 (IL-10), initially known as Cytokine Synthesis Inhibitory Factor (CSIF), belongs to the IL-10 family and shares more than 80% sequence homology with the Epstein-Barr Virus protein BCRFI.

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IL-10 c.-592C>A (rs1800872) polymorphism is associated with cervical cancer. Pereira APL, Trugilo KP, Okuyama NCM, Sena MM, Couto-Filho JD, Watanabe MAE, de Oliveira KBPereira APL, et al. J Cancer Res Clin Oncol, 2020 Aug. PMID 32447484; Association between interleukin-10-819T/C polymorphism and risk of ischemic stroke: A meta-analysis.

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